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Distribution of the efficacy–effectiveness (EE) factor based on start date of first-line systemic treatment, per regimen. For all regimens the median EE factor is significantly different from test value 1.0 (one-sample Wilcoxon signed-rank test), with p-values of p<0.05. cis: cisplatin; pem: pemetrexed; gemci: gemcitabine; carbo: carboplatin; beva: bevacizumab; pacli: paclitaxel; doce: docetaxel.
