Fig 1. Predicted 2D folding pattern of GPR in bilayer membrane along with key residues in sequence.

Sequence numbering given is for the Monterey Bay eBAC31A08 variant of GPR. The key carboxylate groups Asp97 and Glu108 (blue), Schiff base-forming residue Lys231 (orange) and His75 (green) are highlighted. The two residues Asp212 and Phe234 which are substituted with an Asn and Ser, respectively, to form GPR-DNFS are shown in red with white lettering. Reprinted in modified form from [22] under a CC BY license, with permission from the American Society for Biochemistry and Molecular Biology.