Table 3.

Association of subsegmental brain region volumes with lifetime MDD according to 5-HTTLPR genotype

	LL (n = 160)			SL (n = 250)			SS (n = 124)
5-HTTLPR	No lifetime MDD (n = 112), mean ± SD*	Lifetime MDD (n = 48), mean ± SD*	p value†	No lifetime MDD (n = 184), mean ± SD*	Lifetime MDD (n = 66), mean ± SD*	p value†	No lifetime MDD (n = 93), mean ± SD*	Lifetime MDD (n = 31), mean ± SD*	p value†
Rostral anterior cingulate cortex	3 394.88 ± 60.80	3 537.88 ± 94.35	0.22	3 345.48 ± 43.42	3 400.87 ± 74.31	0.52	3 346.62 ± 63.48	3 498.30 ± 112.93	0.24
Insula	11 847.14 ± 99.97	11 963.30 ± 155.14	0.54	11 996.04 ± 78.88	11 628.15 ± 134.99	0.020	11 833.83 ± 103.71	11 520.94 ± 184.48	0.14
Thalamus	11 966.39 ± 98.90	11 376.42 ± 153.47	0.002	11 843.10 ± 65.47	11 700.58 ± 112.05	0.27	11 685.44 ± 89.60	11 717.36 ± 159.39	0.86
Ventral diencephalon	6 726.12 ± 57.73	6 524.76 ± 89.59	0.07	6 869.44 ± 46.83	6 659.23 ± 80.15	0.025	6 765.45 ± 59.92	6 731.95 ± 106.59	0.78
Putamen	9 530.94 ± 131.13	9 093.75 ± 203.49	0.08	9 591.21 ± 75.65	9 323.70 ± 129.47	0.08	9 257.61 ± 108.03	8 955.26 ± 192.18	0.17
Nucleus accumbens	996.60 ± 14.19	966.80 ± 22.02	0.27	1 003.50 ± 11.03	984.31 ± 18.88	0.38	980.00 ± 16.80	921.09 ± 29.89	0.09
Pallidum	2 957.48 ± 32.98	2 852.01 ± 51.18	0.10	3 033.56 ± 24.32	2 952.72 ± 41.62	0.10	2 994.12 ± 37.38	2 869.91 ± 66.50	0.11
Pericalcarine region	3 422.87 ± 54.66	3 509.63 ± 84.83	0.41	3 362.83 ± 47.23	3 639.30 ± 80.83	0.003	3 444.39 ± 56.29	3 512.98 ± 100.13	0.55
Lingual region	10 870.88 ± 135.40	10 875.23 ± 210.12	0.99	10 620.67 ± 110.25	11 142.98 ± 188.68	0.018	10 943.15 ± 133.37	10 991.36 ± 237.26	0.86

MDD = major depressive disorder; SD = standard deviation.

^*Values expressed in mm³ and adjusted for age, sex and total brain volume.

^†Raw p values.