Table 2.
Carrier frequencies for rare variants found in the study.
| Control n = 46 | Severe HTG n = 103 | Subgroup 1 n = 58 | Subgroup 2 n = 45 | |
|---|---|---|---|---|
| LPL | 0(0) | 9(8·7)⁎ | 4(6·9)+ | 5(11·1)# |
| LMF1 | 2(4·3) | 11(10·7) | 6(10·3) | 5(11·1) |
| GPIHBP1 | 2(4·3) | 2(1·9) | 1(1·7) | 1(2·2) |
| APOA5 | 0(0) | 7(6·8)⁎ | 3(5·2) | 4(8·9)# |
| GCKR | 2(4·3) | 8(7·8) | 4(6·9) | 4(8·9) |
| CETP | 0 | 1(1·0) | 1(1·7) | 0 |
| TRIB1 | 0 | 3(2·9) | 2(3·4) | 1(2·2) |
| APOE | 1(2·2) | 4(3·9) | 1(1·7) | 3(6·7) |
| APOB | 7(15·2) | 15(14·6) | 9(15·5) | 6(13·3) |
| APOA4 | 1(2·2) | 2(1·9) | 1(1.7) | 1(2·2) |
| APOA1 | 0 | 2(1·9) | 0 | 2(4·4) |
| ANGPTL3 | 0 | 2(1·9) | 1(1·7) | 1(2·2) |
| LPL molecular regulating variant | 4(8·7) | 26(25·2)⁎ | 13(22·4) | 13(28·9)# |
| APOA1/C3/A4/A5 variant | 1(2·2) | 10(9·7) | 3(5·2) | 7(15·6) |
| ≥1 variant in all sequenced genes | 12(26·1) | 46(44·7)⁎ | 26(44·8)+ | 20(44·4) |
⁎
p < 0.05 for statically significant difference between control group and Severe HTG group.
+
p < 0.05 for statically significant difference between control group and subgroup 1 (5·65 ≤ TG < 11·30 mmol/L).
#
p < 0.05 for statically significant difference between control group and subgroup 2(TG ≥ 11·30 mmol/L).