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. 2018 Nov 27;38:79–88. doi: 10.1016/j.ebiom.2018.11.030

Fig. 3.

Fig. 3

Formulation and characterization of MECA79-Taxol-NPs. (a) Representative TEM images of Taxol-NP (Scale bar = 100 nm) (b) Hydrodynamic diameter of non-conjugated and MECA79-conjugated Taxol-NPs. The data are presented as the mean and SEM (n = 6). (c) Release kinetics of Taxol from NPs over one-week. The data are presented as the mean and SEM (n = 3). (d) Taxol-NPs induced similar levels of apoptosis in pancreatic cancer cells in vitro in comparison to free Taxol. (e) The MFI of tumors showed significantly higher accumulation of *Taxol in MECA79-*Taxol-NP group, as compared to *Taxol group (*p < 0.05, student's t-test). The data are presented as the mean and SEM (n = 3). (f) Immunofluorescence staining of PDAC tissue showed that MECA79-*Taxol-NPs (green) were present within the ECM (Collagen IV, in red) of tumor at a higher number, as compared to the control group (Scale bar = 100 μm).