Table 3.
Serum Hormone Concentrations (Median and 25th and 75th Percentiles) by Group on D 28 of Treatment
Parameter (Cavg) | Placebo (n = 23) | C100 (n = 13) | C200 (n = 14) | P200 (n = 13) | P400 (n = 6) | C400 (n = 13) |
---|---|---|---|---|---|---|
Serum LH, IU/L | 3.3(2.8, 4.9) | 0.8 (0.5, 3.7) | 0.6 (0.2, 2.3) | 0.5 (0.2, 1.0) | 0.2 (0.2, 0.2) | 0.2 (0.2, 0.2) |
Serum FSH, IU/L | 2.5(1.7, 4.1) | 1.0 (0.6, 5.1) | 0.4 (0.2, 1.1) | 0.5 (0.2, 1.0) | 0.2 (0.2, 0.2) | 0.2 (0.2, 0.2) |
Serum T, ng/dL | 474(421, 549) | 15.7 (8, 187.5) | 24.3 (11.9, 70.2) | 12.6 (7.5, 29.9) | 7.0 (4.5, 9.9) | 8.3 (5.2, 14.2) |
Subjects with serum T <50 ng/dL, n(%) | 0 (0) | 6 (46.2) | 9 (64.3) | 10 (76.9) | 6 (100) | 12 (92.3) |
Only efficacy-evaluable population data are included here. For serum T, FSH, and LH, Cavg was calculated for each subject. Then medians and 25th and 75th percentiles were calculated from those values by treatment group.