Figure 7.

IGFBP-1 phosphorylation is increased in maternal plasma collected in the first trimester from mothers who later delivered an IUGR infant. Plasma samples were collected from women at 7 to 9 wks of gestation, who later delivered an IUGR or AGA infant. (A) A representative Western blot of total IGFBP-1 in maternal plasma. (B–D) Representative Western blots of IGFBP-1 phosphorylated at Ser101, Ser119, and Ser169 in maternal plasma. The scatter plots summarize the Western blot data. Values are given as means ± SEM; n = 3 in the AGA group and n = 4 in the IUGR group; P < 0.05 vs control; unpaired t test.