Fig. 1.

Proposed model for the interplay of APP and ADAM10 in breast cancer cell migration. APP and ADAM10 are upregulated in breast cancer tissue increasing the chance of APP cleavage. Soluble APPα formation is relevant for induction of breast cancer cell migration via yet undefined pathways. Further research (blue boxes) is warranted to clarify the trafficking and activation of ADAM10 leading to APP shedding e.g. the involvement of tetraspanins. Furthermore, APP receptor binding, formation of heterooligomers and signalling need to be investigated including integrin binding via FE65, activation of G-proteins and further downstream kinases (e.g. PKA, PI3K, Akt and FAK) involved in the regulation of cell motility and proliferation.