Table 3.
RNFL thickness values in OCT by quadrant in children with NF-1 and the corresponding optic nerve function findings.
| Pt. no. | RNFL thickness (μm) 1st OCT | RNFL thickness (μm) last OCT | OPG Location | Initial optic nerve function (Last) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Ave | SQ | IQ | NQ | TQ | Ave | SQ | IQ | NQ | TQ | VA (LogMar) | Color vision* | RAPD | Disc | VF | |||
| 1 | RE | 45 | 61 | 56 | 35 | 31 | 41 | 49 | 53 | 34 | 27 | ON, CG | NLP (NLP) | 0.0 (0.0) | + (+) | Atrophy | None |
| LE | – | – | – | – | – | 43 | 62 | 49 | 35 | 23 | 0.3 (0.3) | 0.5 (0.3) | – (–) | Atrophy | Temporal (Temporal) | ||
| 2 | RE | 97 | 107 | 130 | 85 | 68 | 78 | 71 | 119 | 62 | 63 | CG, HT | 0.0 (0.0) | 0.8 (1.0) | – (–) | Normal (Normal) | Normal (Normal) |
| LE | 96 | 104 | 130 | 95 | 53 | 82 | 78 | 123 | 50 | 79 | 0.0 (0.0) | 1.0 (1.0) | – (–) | Normal (Normal) | Normal (Normal) | ||
| 3 | RE | 110 | 130 | 125 | 96 | 88 | – | – | – | – | – | ON | 0.0 (0.1) | 1.0 (1.0) | – (–) | Normal (Normal) | Normal (Normal) |
| LE | 102 | 122 | 105 | 96 | 84 | – | – | – | – | – | 0.0 (0.1) | 1.0 (1.0) | – (–) | Normal (Normal) | Normal (Normal) | ||
| 4 | RE | 86 | 98 | 120 | 67 | 61 | 90 | 113 | 118 | 66 | 63 | ON, CG | 0.0 (0.0) | 1.0 (1.0) | – (–) | Normal (Normal) | Normal (Normal) |
| LE | 71 | 81 | 95 | 67 | 41 | 69 | 74 | 99 | 61 | 40 | 0.0 (0.0) | 1.0 (1.0) | – (–) | Normal (Normal) | Normal (Nasal) | ||
| 5 | RE | 76 | 108 | 91 | 56 | 52 | – | – | – | – | – | ON | 0.0 (0.1) | YO (1.0) | – (–) | Normal (Pale) | Normal (Normal) |
| LE | 73 | 81 | 104 | 56 | 54 | – | – | – | – | – | 0.0 (0.0) | YO (1.0) | – (–) | Normal (Pale) | Normal (Normal) | ||
| 6 | RE | 60 | 73 | 73 | 52 | 42 | 49 | 51 | 59 | 52 | 34 | ON, OT, CG, HT | 0.2 (0.2) | 1.0 (0.5) | – (–) | Pale (Atrophy) | Bitemporal (Temporal) |
| LE | 57 | 70 | 53 | 56 | 49 | 48 | 51 | 50 | 50 | 40 | 1.2 (HM) | 0.3 (0.0) | – (+) | Atrophy (Atrophy) | Bitemporal (None) | ||
| 7 | RE | 86 | 116 | 100 | 71 | 58 | 78 | 107 | 86 | 48 | 72 | OT | 0.2 (0.0) | 1.0 (1.0) | – (–) | Normal (Normal) | Normal (Bitemporal) |
| LE | 89 | 111 | 96 | 78 | 72 | 87 | 110 | 97 | 70 | 72 | 0.0 (0.0) | 1.0 (1.0) | – (–) | Normal (Normal) | Normal (Bitemporal) | ||
| 8 | RE | 101 | 109 | 141 | 85 | 68 | – | – | – | – | – | ON, OT, CG, HT | 0.0 (0.0) | 1.0 (1.0) | – (–) | Normal (Normal) | Normal (Normal) |
| LE | 99 | 130 | 132 | 69 | 64 | – | – | – | – | – | 0.0 (0.0) | 1.0 (1.0) | – (–) | Normal (Normal) | Normal (Normal) | ||
| 9 | RE | 113 | 173 | 111 | 67 | 102 | – | – | – | – | – | ON, CG | 0.0 (0.0) | 1.0 (1.0) | – (–) | Normal (Normal) | Normal (Normal) |
| LE | 47 | 51 | 59 | 42 | 35 | – | – | – | – | – | 0.0 (0.0) | 1.0 (1.0) | + (+) | Atrophy (Atrophy) | Nasal (Nasal) | ||
| 10 | RE | 106 | 110 | 137 | 88 | 64 | – | – | – | – | – | ON, OT, CG, HT | 0.0 (0.0) | 0.8 (1.0) | – (–) | Normal (Normal) | Normal (Normal) |
| LE | 108 | 133 | 137 | 95 | 67 | – | – | – | – | – | 0.0 (0.0) | 0.8 (1.0) | – (–) | Normal (Normal) | Normal (Normal) | ||
OCT, optical coherence tomography; Ave, average; SQ, superior quadrant; IQ, inferior quadrant; NQ, nasal quadrant; TQ, temporal quadrant; VA, visual acuity; YO, too young to perform; RAPD, relative afferent pupillary defects; VF, visual fields; HOMHEM, homonymous hemianopia; ON, Optic nerve glioma; OT, Optic tract glioma; CG, Chiasmatic glioma; HT, Hyopthalamic glioma.
*
Ishihara color plates detected.