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. 2018 Dec 20;11:466. doi: 10.3389/fnmol.2018.00466

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Copyright © 2018 Mlost, Wąsik, Michaluk, Antkiewicz-Michaluk and Starowicz.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The effect of URB597 on OA-produced decreases in noradrenergic neurotransmission in the investigated brain structures; (A,C,E) FCx and (B,D,F) HC. Samples were collected 28 days after OA induction, 1 h after i.p. administration of URB597 or vehicle. Data are presented as the mean ± SEM and represent normalized averages derived from 6 to 10 samples for each group. The results were analyzed by means of one-way ANOVA, followed by Duncan’s post hoc tests. Statistical significance: *P < 0.05, **P < 0.01 vs. Control group; ^#P < 0.05, ^#^#P < 0.01 vs. OA group. One-way ANOVA indicated a significant effect of OA on the rate of noradrenaline (NA) metabolism in FCx (F_(3,22) = 5.69; P < 0.004) and HC (F_(3,22) = 6.88; P < 0.001); NM concentration in FCx (F_(3,22) = 5.66, P < 0.004) and HC (F_(3,22) = 8.92, P < 0.0004) and NA concentration in the HC (F_(3,22) = 9.99, P < 0.0002).