Table 5.

Methodological quality of the rodent experimental studies.

Quality category	No. of studies with quality
Peer reviewed publication	14
Control of temperature	10
Random allocation to treatment or control	5
Blinded induction of ischemia	0
Blinded assessment of outcome	5
Use of anesthetic without significant intrinsic neuroprotective activity	1
Animal model (aged, diabetic, or hypertensive)	14
Sample size calculation	14
Compliance with animal welfare regulations	10
Statement of potential conflict of interests	9

The scale used was originally proposed by Macleod et al. with a possible maximum score of 10. One point is given for each criterion met.