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. 2018 Nov 2;38:25–36. doi: 10.1016/j.ebiom.2018.10.069

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 5 — Sal inhibits HIF-1 α signaling pathway. (A) Protein expression level of HIF-1α after treatment with the protein synthesis inhibitor CHX in PLC/PRF/5 cells. (B) Protein expression level of HIF-1α after treatment with the proteasome inhibitor MG132 in PLC/PRF/5 cells. (C) Protein expression level after incubation with the proteasome inhibitor in PLC/PRF/5 cells. (D) Protein expression level of HIF-1α after overexpression of mutational HIF-1α in PLC/PRF/5 cells. (E-F) Cell migration was measured after overexpression of mutational HIF-1α in PLC/PRF/5 cells. (G-H) Representative images of Transwell cell invasion assays after overexpression of mutational HIF-1α in PLC/PRF/5 cells. (I) The relative IC₅₀ values for OXA of PLC/PRF/5 after overexpression of mutational HIF-1α. Error bars represent the standard deviation of experiments performed in triplicate (*P < .05, **P < .01).