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Derivation (early sepsis) cohort (N = 342). Time to event curves for 1-year death or infection-related readmission according to PCSK9 genotype groups. Patients carrying multiple PCSK9 LOF alleles showed significantly decreased risk for this outcome in comparison to patients carrying no (wildtype) or one PCSK9 LOF allele (P = 0.018). One patient (WT group) was excluded from this analysis as the time to the composite outcome was not ascertained.
