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Derivation (early sepsis) cohort (N = 132). PCSK9 levels at sepsis admission according to PCSK9 genotype (Ref. vs. multiple LOF group). Patients carrying multiple PCSK9 LOF alleles (N = 23) had lower PCSK9 levels than patients from the Ref. group (N = 109) (P = 0.037). Ref. indicates WT/Single PCSK9 LOF allele group.
