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Meta-analysis of 90-day mortality of Derivation and Validation cohorts (N = 1481). The presence of multiple PCSK9 alleles had an overall protective effect for this outcome (OR = 0.69, 95% C.I. 0.50–0.94, P = 0.02). (M-H: Mantel-Haenszel). Ref. indicates WT/Single PCSK9 LOF allele group.
