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. 2018 Nov 23;38:257–264. doi: 10.1016/j.ebiom.2018.11.032

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© 2018 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

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Fig. 4 — Blood counts during sepsis (from day 0 to day 14) according to PCSK9 genotype. X-axis represents time in day (0 to 14); Y-axis represents the respective blood cell counts for each panel; black circles represent mean values over time in Ref. patients; red squares represent mean values over time in multiple LOF patients. A) Derivation Cohort. Left panel: White blood cell (WBC) counts. Right panel: Neutrophil counts; B) Validation Cohort: WBC counts. Patients carrying multiple PCSK9 LOF alleles demonstrated greatly decreased absolute neutrophil counts in the Derivation Cohort (P = 0.01), and WBC counts in the Validation Cohort (P = 0.007) in comparison to Ref. patients. Ref. indicates WT/Single PCSK9 LOF allele group.