Table 1.
Derivation Cohort: Baseline characteristics according to PCSK9 genotype.
| Variable | All patients N = 342 |
Ref.a N = 290 |
Multiple LOF N = 52 |
P value |
|---|---|---|---|---|
| Age, Median (IQR) | 59 (44–69) | 59 (44–70) | 57 (43–65) | 0.515 |
| Gender (N, % male) | 226 (66.1) | 190 (65.5) | 36 (69.2) | 0.717 |
| Ethnicity (N, % Caucasians)b | 209 (61.1) | 173 (59.7) | 36 (69.2) | 0.250 |
| HR, Median (IQR)c | 108 (91–127) | 107 (91–126) | 115 (90–136) | 0.316 |
| MAP, Median (IQR)c | 58 (53–67) | 59 (53–67) | 58 (55–70) | 0.482 |
| Temperature, Median (IQR)c | 37.5 (36.5–38.4) | 37.5 (36.5–38.3) | 37.8 (36.4–39.0) | 0.568 |
| APACHE II score, Median (IQR) | 14 (7–19) | 14 (8–19) | 12 (7–21) | 0.989 |
| ICU (N, %) | 245 (71.6) | 207 (71.4) | 38 (73.1) | 0.934 |
| HGB g/L, Median (IQR)d | 112 (92–130) | 112 (93–130) | 106 (90–127) | 0.385 |
| WBC (x109), Median (IQR)d | 10.6 (6.3–15.0) | 10.7 (6.4–15.1) | 10.4 (5.9–13.3) | 0.520 |
| Platelets (x109), Median (IQR)d | 186 (131–271) | 190 (133–267) | 175 (110–284) | 0.542 |
| Creatinine (mmol/l), Median (IQR)d | 89 (65–154) | 89 (66–152) | 90 (55–158) | 0.651 |
| INR, Median (IQR)d | 1.2 (1.1–1.5) | 1.2 (1.1–1.5) | 1.2 (1.1–1.5) | 0.616 |
| Lactate (mmol/l), Median (IQR)d | 1.6 (1.1–2.6) | 1.6 (1.2–2.6) | 1.3 (1.0–2.7) | 0.424 |
| COPD (N, %) | 60 (17.5) | 48 (16.6) | 12 (23.1) | 0.347 |
| Chronic renal failure (N, %) | 15 (4.4) | 11 (4.0) | 4 (7.7) | 0.271 |
| Cirrhosis (N, %) | 10 (2.9) | 9 (3.1) | 1 (1.9) | 0.985 |
| CHF NYHA Class 3 or 4 (N, %) | 29 (8.5) | 25 (8.6) | 4 (7.6) | 0.982 |
| Hypertension (N, %) | 88 (25.7) | 78 (26.9) | 10 (19.2) | 0.321 |
| Diabetes mellitus (N, %) | 54 (15.8) | 46 (15.8) | 9 (15.4) | 0.913 |
| Statins use (N, %)e | 51 (27.9) | 42 (27.8) | 9 (28.1) | 0.972 |
Abbreviations: LOF: Loss-of-function; IQR: Interquartile Range; HR: Heart Rate; RR: Respiratory Rate; SpO2: arterial Oxygen Saturation; MAP: Mean Arterial Pressure; APACHE: Acute Physiology and Chronic Health Evaluation; ICU: Intensive Care Unit; AKI: Acute Kidney Injury; HGB: Hemoglobin; WBC: White Blood Cell; COPD: Chronic Obstructive Pulmonary Disease; CHF: Congestive Heart Failure; NYHA: New York Heart Association.
a
Ref. indicates WT/Single PCSK9 LOF allele group.
b
Determined by the study coordinator or research assistant.
c
Parameters measured at admission.
d
Measurements in the first 24 h of ED admission; e Available in 183 patients.