Table 1.
Demographics, clinical measures, and covariatesa.
| SZ (n = 34) | HC (n = 23) | t/χ2 | p-value | |
|---|---|---|---|---|
| Gender (%male) | 73.5 | 82.6 | 0.642 | 0.423 |
| Age | 28.32 (9.42) | 27.48 (9.63) | −0.330 | 0.743 |
| Socioeconomic statusb | 5.88 (5.06)c | 4.65 (3.97) | 12.849 | 0.303 |
| Smoking (packs per day) | 0.37 (0.49) | 0.18 (0.41) | −1.564 | 0.124 |
| Illness duration (years)d | 15.00 (8.45) (n = 12) | |||
| Illness onset (years)d | 22.08 (3.12) | |||
| APD naïve (yes/ no) | 22/12 | |||
| eTIVe | 1593.70 (182.36) | 1658.79 (230.71) | 1.187 | 0.240 |
| SNR | 19.93 (1.98) | 20.50 (2.07) | 1.069 | 0.290 |
| BPRSf | Baseline | Week 6 | ||
| Total | 50.91 (9.65) | 32.50 (10.45) | 7.545 | <0.001 |
| Positive | 10.44 (3.47) | 5.18 (2.41) | 7.277 | <0.001 |
| Negative | 7.44 (3.16) | 5.85 (2.74) | 2.215 | 0.030 |
SZ, schizophrenia; HC, healthy controls; APD, antipsychotic drug; eTIV, Estimated total intracranial volume; SNR, signal to noise ratio; BPRS, Brief Psychiatric Rating Scale.
Mean (SD) unless indicated otherwise.
Parental socioeconomic ranks determined from Diagnostic Interview for Genetic Studies (1–18 scale), higher rank (lower numerical value) corresponds to higher socioeconomic status.
Data not available for 2 SZ subjects, n = 32.
Includes only patients who are not antipsychotic naïve (n = 12), illness duration since first diagnosis.
Estimated total intracranial volume (eTIV) in cm2.
BPRS (1–7 scale); positive (conceptual disorganization, hallucinatory behavior, and unusual thought content); negative (emotional withdrawal, motor retardation, and blunted affect).