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The A2AR–D2R heterotetramer–AC5 complex. Schematic slice-representation, viewed from the extracellular side, of the minimal functional unit of the A2AR–D2R heterotetramer in complex with Gs (more specifically Golf) and Gi proteins and adenyl cyclase (subtype AC5), in the absence (A) and presence (B) of A2AR and D2R agonists, which induce a rearrangement of the heterotetramer–AC5 interfaces (modified from Ferré et al.3). A2AR–D2R, adenosine A2A receptor–dopamine D2 receptor.
