Table 3.
Multivariate Regression of Individual Biomarker on Levels of Vitamin D Metabolites by HIV Status
| HIV+ (N = 466) | HIV− (N = 192) | HIV+ (N = 466) | HIV− (N = 192) | |||||
|---|---|---|---|---|---|---|---|---|
| Mean difference in 25(OH)D, (95% CI) | p-Value | Mean difference in 25(OH)D, (95% CI) | p-Value | Mean difference in 1,25(OH)2D, (95% CI) | p-Value | Mean difference in 1,25(OH)2D, (95% CI) | p-Value | |
| sTNF-R2 | 0.20 (−0.57 to 0.97) | .606 | 0.51 (−0.75 to 1.77) | .428 | −2.26 (−3.69 to −0.82) | .002 | −2.78 (−4.98 to −0.57) | .014 |
| sCD27 | 0.43 (−0.37 to 1.24) | .291 | −0.30 (−1.50 to 0.90) | .620 | −1.56 (−3.02 to −0.09) | .037 | −2.18 (−4.48 to 0.12) | .063 |
| sIL-2Rα | 0.28 (−0.46 to 1.02) | .455 | 0.46 (−0.52 to 1.44) | .360 | −1.05 (−2.54 to 0.44) | .168 | −1.12 (−3.16 to 0.92) | .283 |
| BAFF | −0.63 (−1.37 to 0.11) | .096 | −0.48 (−1.96 to 0.99) | .522 | −0.74 (−2.05 to 0.56) | .265 | −1.47 (−4.12 to 1.17) | .274 |
| sgp130 | 0.17 (−0.58 to 0.93) | .651 | 0.08 (−1.16 to 1.31) | .905 | −0.76 (−2.29 to 0.77) | .332 | −0.72 (−2.60 to 1.17) | .456 |
| sCD14 | 0.45 (−0.37 to 1.27) | .279 | 0.03 (−0.87 to 0.94) | .941 | 0.91 (−0.48 to 2.30) | .198 | 0.53 (−1.55 to 2.60) | .617 |
| IP-10 | 0.20 (−0.66 to 1.06) | .654 | 1.53 (0.34 to 2.72) | .012 | −0.36 (−1.76 to 1.03) | .609 | −0.34 (−3.43 to 2.75) | .830 |
| sIL-6R | 0.37 (−0.36 to 1.11) | .320 | 0.11 (−0.74 to 0.96) | .796 | −0.72 (−1.84 to 0.39) | .202 | 0.77 (−1.93 to 3.47) | .578 |
| TNF-α | 0.09 (−0.69 to 0.87) | .822 | 0.20 (−0.48 to 0.88) | .557 | −1.28 (−2.96 to 0.39) | .134 | −1.76 (−2.74 to −0.78) | <.001 |
| IL-6 | −0.30 (−1.21 to 0.62) | .528 | −0.10 (−0.99 to 0.78) | .819 | −1.13 (−2.78 to 0.53) | .181 | −0.96 (−2.27 to 0.36) | .154 |
| IL-8 | −0.23 (−1.08 to 0.61) | .590 | −0.28 (−1.05 to 0.49) | .482 | 0.18 (−1.38 to 1.74) | .818 | −1.21 (−3.14 to 0.71) | .216 |
| MIP-1 | −0.55 (−1.44 to 0.34) | .229 | 0.23 (−0.62 to 1.08) | .592 | 0.90 (−0.57 to 2.36) | .229 | 2.52 (0.20 to 4.84) | .033 |
| MCP-1 | 0.57 (−0.29 to 1.42) | .194 | −0.70 (−2.03 to 0.63) | .302 | −0.53 (−1.85 to 0.79) | .431 | −0.24 (−2.39 to 1.91) | .827 |
| Eotaxin | 0.82 (0.00 to 1.65) | .049 | −0.78 (−2.02 to 0.46) | .217 | 1.11 (−0.28 to 2.49) | .117 | −0.78 (−3.10 to 1.54) | .508 |
| MCP-4 | 0.28 (−0.47 to 1.04) | .462 | 0.65 (−0.58 to 1.88) | .302 | 0.82 (−0.49 to 2.13) | .222 | 1.22 (−0.97 to 3.41) | .276 |
The concentration of each biomarker had been natural log-transformed and then standardized with mean = 0 and standard deviation = 1.
The model was adjusted for age, BMI, and HCV infection. An example of interpretation is that one SD increase of Eotaxin was significantly associated with 0.82 pg/mL higher levels of 25(OH)D in HIV+.
Bold font refers to P-value <0.05 from the multivariate regression model.
CI, confidence interval; HCV, hepatitis C virus.