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. 2018 Nov 27;7(12):488. doi: 10.3390/jcm7120488

Figure 6.

Figure 6

Pharmacological regulation of pluripotency circuitry establishment during cellular reprogramming via the FEN-stimulated PPARα regulatory pathway. Nr5a2 increased by FEN may interact with Nr0b1 and function in Oct4 upregulation together, resulting in the target activation of Oct4 itself, Rex1, and Nanog. Nanog was also identified as a direct target of PPARα and then transcriptionally activated with or without coactivators.