Table 3.
Factors associated with mortality in patients with Elizabethkingia infections.
| Factor | Outcome | Univariate Analysis | Multivariate Analysis | |||
|---|---|---|---|---|---|---|
| Died | Survived | OR (95% CI) | p-Value | OR (95% CI) | p-Value | |
| All Isolates (n = 92) | ||||||
| Species | ||||||
| E. meningoseptica | 6 (24) | 14 (20.9) | 1.2 (0.4–3.56) | 0.748 | 1.76 (0.5–6.16) | 0.38 |
| E. anophelis | 19 (76) | 53 (79.1) | 0.748 | 0.57 (0.16–2) | 0.38 | |
| Age ≥65 years | 12 (48) | 29 (43.3) | 1.21 (0.48–3.04) | 0.686 | 2.89 (0.86–9.74) | 0.087 |
| Sex, male | 20 (80) | 44 (65.7) | 2.09 (0.7–6.3) | 0.184 | 2.99 (0.78–11.52) | 0.112 |
| Underlying disease | ||||||
| Diabetes mellitus | 8 (32) | 16 (23.9) | 1.5 (0.55–4.12) | 0.43 | 1.56 (0.44–5.49) | 0.491 |
| Hypertension | 4 (16) | 22 (32.8) | 0.39 (0.12–1.27) | 0.111 | 0.27 (0.07–1.11) | 0.069 |
| End-stage renal disease | 1 (4) | 4 (6) | 0.66 (0.07-6.17) | 0.999 | 0.45 (0.03–6.77) | 0.566 |
| Malignancy | 12 (48) | 28 (41.8) | 1.29 (0.51–3.24) | 0.593 | 1.11 (0.35–3.47) | 0.86 |
| Liver cirrhosis | 5 (20) | 3 (4.5) | 5.33 (1.17–24.31) | 0.032 | 4.67 (0.9–24.3) | 0.067 |
| Chronic obstructive pulmonary disease | 4 (16) | 5 (7.5) | 2.36 (0.58–9.62) | 0.248 | 1.98 (0.28–18.87) | 0.492 |
| Inappropriate empirical antimicrobial therapy | 24 (96) | 50 (74.6) | 8.16 (1.03–64.97) | 0.02 | 12.45 (1.33–116.77) | 0.027 |
| E. meningoseptica (n = 20) | ||||||
| Age ≥65 years | 3 (50) | 4 (28.6) | 2.5 (0.35–18.04) | 0.613 | 0.999 | |
| Sex, male | 5 (83.3) | 10 (71.4) | 2 (0.17–22.95) | 0.999 | 0.999 | |
| Underlying disease | ||||||
| Diabetes mellitus | 2 (33.3) | 4 (28.6) | 1.25 (0.16–9.77) | 0.999 | 4.5 (0.31–65.23) | 0.27 |
| Hypertension | 0 | 4 (28.6) | 0.267 | 0.999 | ||
| End-stage renal disease | 0 | 1 (7.1) | 0.999 | 0.999 | ||
| Malignancy | 2 (33.3) | 6 (42.9) | 0.67 (0.09–4.93) | 0.999 | 0.68 (0.03–17.96) | 0.814 |
| Liver cirrhosis | 2 (33.3) | 1 (7.1) | 6.5 (0.46–91.92) | 0.202 | 5.11 (0.3–87.96) | 0.261 |
| Chronic obstructive pulmonary disease | 0 | 0 | ||||
| Inappropriate empirical antimicrobial therapy | 6 (100) | 0 | ||||
| E. anophelis (n = 72) | ||||||
| Age ≥65 years | 9 (47.4) | 25 (47.2) | 1.01 (0.35–2.88) | 0.988 | 1.81 (0.36–8.97) | 0.47 |
| Sex, male | 15 (78.9) | 34 (64.2) | 2.1 (0.61–7.22) | 0.235 | 2.09 (0.53–8.19) | 0.291 |
| Underlying disease | ||||||
| Diabetes mellitus | 6 (31.6) | 12 (22.6) | 1.58 (0.49–5.04) | 0.539 | 1.44 (0.36–5.76) | 0.606 |
| Hypertension | 4 (21.1) | 18 (34) | 0.52 (0.15–1.79) | 0.295 | 0.36 (0.09–1.46) | 0.153 |
| End-stage renal disease | 1 (5.3) | 3 (5.7) | 0.93 (0.09–9.48) | 0.999 | 0.66 (0.04–10.92) | 0.773 |
| Malignancy | 10 (52.6) | 22 (41.5) | 1.57 (0.55–4.49) | 0.403 | 1.3 (0.34–4.98) | 0.706 |
| Liver cirrhosis | 3 (15.8) | 2 (3.8) | 4.78 (0.73–31.19) | 0.111 | 3.4 (0.51–22.5) | 0.204 |
| Chronic obstructive pulmonary disease | 4 (21.1) | 5 (9.4) | 2.56 (0.61–10.77) | 0.231 | 3.06 (0.59–15.9) | 0.183 |
| Inappropriate empirical antimicrobial therapy | 18 (94.7) | 36 (67.9) | 8.5 (1.05–69.04) | 0.021 | 8.5 (1.05–69.04) | 0.045 |
Abbreviations: OR, odds ratio; CI, confidence interval.