Table 3.

Reports of relapses of multiple sclerosis (MS) with assisted reproduction technology (ART).

Study	Type of Study	No of Patients	No of ART Cycles	Relapses with GnRH Agonists	Relapses with GnRH Antagonists	Reference
Laplaud et al., 2006	Retrospective	6	10	5/6 treatments	0/4 treatments	[130]
Hellwig et al., 2008	Retrospective	6	14	3/9 treatments	2/5 treatments	[131]
Hellwig et al., 2009	Prospective/retrospective	23	78	Increased annualized relapse rate (ARR)	Increased ARR	[132]
Hellwig et al., 2009	Prospective group	10	14	2/8	1/4	[132]
Correale et al., 2012	Prospective	16	26	15/26	Not applicable	[133]
Michel et al., 2012	Retrospective	32	70	Increased ARR (48 treatments)	No increased ARR (19 treatments)	[134]