Figure 3.

Trial conduct: The Lollipop plot depicts HIPEC clinical trials performed between 1981 and 2016 and published from 1994 to 2017 with different cytostatic drugs (only reports with n > 4 patients and protocols containing MMC or L-OHP single drug or combinations were included). Green dots signify year of trial initiation, blue dots end of recruitment, red crossed markers point to publication dates. Symbols are lg scaled according to number of patients included in the respective study. Publications conform to annotations given in Tables S1–S5, with Arabic letters marking chronological order (if required). Abbreviations used: CDDP (cisplatin); DOX (doxorubicin); IRI (irinotecan); L-OHP (oxaliplatin); and MMC (mitomycin c).