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. 2018 Nov 28;7(12):496. doi: 10.3390/jcm7120496

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© 2018 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).

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Histopathological aspects and positive immunostaining of the ZIKV-infectedmiscarriage (Case 1). (A) Embryonic tissue (black arrow) within the yolk sac (blue arrow) and placenta (red arrow) (HE, 100×). (B) Positive immunostaining for ZIKV antigens in embryonic tissue (IHC, SAAP, 400×). (C,D) Positive immunostaining for ZIKV in placental chorionic villi (IHC, SAAP, 400×). (E) Positive immunostaining to ZIKV observed in the liver in hepatocytes (circle) (Case 3) (IHC, SAAP, 400×). (F) Positive immunostaining to ZIKV observed in the kidney in renal tubule (black arrows) (Case 3) (IHC, SAAP, 400×).