Table 1.
Information about the 12 fatal cases of Zika virus (ZIKV) infection.
| Case | State | Category | Lifetime | Sex | Date Birth (m/d/y) | Date Death (m/d/y) | Gestational Age | Maternal DOS | Maternal Symptoms | Case Information | Material |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ES | Fetus (Miscarriage) | NA | NA | 12/24/2015 | 12/24/2015 | 8 weeks | No symptoms | No symptoms | Ultrasound (8 weeks) detected retained dead fetus. Fetal skull disproportionately smaller than the trunk | fetus, placenta |
| 2 | RN | Stillbirth | NA | M | 01/12/2016 | 01/12/2016 | 34 weeks (Preterm) | Unknown | Unknown | Macroscopic aspects: brain malformed, dilated lateral ventricles and the absence of the cerebellum; absence of nasal bone, clubfoot; bilateral cubital fold; absence of scrotum; hypoplastic penis; bilateral cryptorchidism | brain, liver, kidney, lung |
| 3 | PE | Stillbirth | NA | F | 12/16/2015 | 12/16/2015 | 40 weeks (At term) | Unknown | Urinary tract infection treated during pregnancy | Microcephaly detected at birth | brain, liver, spleen, heart, kidney, lung, placenta |
| 4 | RN | Newborn | 2 h | M | 11/14/2015 | 11/14/2015 | Unknown | First trimester | Symptoms suggestive of Zika infection | Newborn with microcephaly, large anterior fontanel, nasopalatine cleft, low-set ears, ginodactyly, clubfoot | brain, liver, kidney, lung |
| 5 | RN | Newborn | 6 h | F | 11/17/2015 | 11/17/2015 | 40 weeks (At term) | Before confirmation of pregnancy | General symptoms of viral disease and rash | Microcephaly with ventriculomegaly, arthrogryposis, pulmonary hypoplasia, atrial septal defect | brain, liver, kidney, lung |
| 6 | RN | Newborn | 14 h | M | 01/07/2016 | 01/07/2016 | Unknown | Unknown | Unknown | Newborn with microcephaly (CP = 32 cm) and hydrocephalus, arthrogryposis. Macroscopic pulmonary hypoplasia, reduced brain tissue, cerebellar hypoplasia, abdominal testis, thoracolumbar scoliosis | brain, liver, kidney, lung |
| 7 | CE | Newborn | 1 day | M | 12/16/2015 | 12/17/2015 | Unknown | Unknown | Unknown | Microcephaly | brain, liver, spleen, heart, kidney, lung, placenta, umbilical cord |
| 8 | CE | Newborn | 2 days | M | 12/30/2015 | 12/31/2015 | Unknown | Unknown | Unknown | Microcephaly | brain, liver, spleen, heart, kidney, lung |
| 9 | PB | Newborn | 1 day | M | 12/26/2015 | 12/26/2015 | 28 weeks (Preterm) | First trimester | Fever and rash | Ultrasound (22 weeks) detected microcephaly, clubfoot, agenesis of fingers. Newborn with microcephaly (CP = 21 cm) and deformities of the hands and feet were observed. Macroscopy: decreased lungs and brain; lung, liver, pancreas, spleen and gut with a wine-like appearance | brain, liver, spleen, heart, kidney, lung |
| 10 | CE | Newborn | 5 min | F | 11/18/2015 | 11/18/2015 | 29 weeks (Preterm) | First trimester | Fever, myalgia, joint pain, and rash | Newborn with microcephaly and arthrogryposis, and possible esophageal atresia | blood, CSF, urine, brain, liver, spleen, thymus, heart, kidney, lung |
| 11 | CE | Newborn | 1 day | F | 12/16/2015 | 12/17/2015 | 36 weeks (Preterm) | Unknown | Unknown | Cesarean delivery for breech presentation, with the presence of meconium. Detected microcephaly (CP = 31 cm) and arthrogryposis. X-ray shows right diaphragmatic hernia | brain, liver, spleen, heart, kidney, lung |
| 12 | CE | Newborn | 1 day | F | 12/22/2015 | 12/22/2015 | At term | Second trimester | Fever and rash | Detected microcephaly (CP = 30 cm) and bilateral ventriculomegaly on 35 weeks of gestational age. | serum, placenta |
DOS: date of onset of symptoms; NA: not applicable; CSF: cerebrospinal fluid; ES: Espírito Santo State; RN: Rio Grande do Norte State; M: Male; F: Femal; CP: cephalic perimeter; PE: Pernambuco State; CE: Ceará State; PB: Paraíba State.