Table 4.
Q1 | Q2 | p-Value | Q3 | p-Value | Q4 | p-Value | BCAA Per 1 SD Increment | p-Value | |
---|---|---|---|---|---|---|---|---|---|
Participants, n | 1561 | 1561 | 1561 | 1561 | 6244 | ||||
Events, n | 27 | 44 | 72 | 158 | 301 | ||||
HR (95% CI) | HR (95% CI) | HR (95% CI) | HR (95% CI) | ||||||
Crude Model | (ref) | 1.65 (1.01, 2.66) | 0.042 | 2.67 (1.71, 4.14) | <0.0001 | 6.15 (4.08, 9.24) | <0.0001 | 1.80 (1.64, 1.98) | <0.0001 |
Model 1 | (ref) | 1.58 (0.97, 2.56) | 0.064 | 2.56 (1.62, 4.05) | <0.0001 | 6.12 (3.92, 9.55) | <0.0001 | 1.76 (1.59, 1.96) | <0.0001 |
Model 2 | (ref) | 1.41 (0.85, 2.32) | 0.178 | 1.87 (1.17, 3.00) | 0.009 | 3.49 (2.19, 5.55) | <0.0001 | 1.46 (1.29, 1.65) | <0.0001 |
Model 3 | (ref) | 1.41 (0.85, 2.33) | 0.175 | 1.87 (1.17, 3.01) | 0.008 | 3.56 (2.24, 5.65) | <0.0001 | 1.48 (1.31, 1.68) | <0.0001 |
Model 4 | (ref) | 1.45 (0.88, 2.41) | 0.142 | 1.84 (1.15, 2.94) | 0.010 | 3.14 (1.99, 4.97) | <0.0001 | 1.39 (1.23, 1.57) | <0.0001 |
Model 5a | (ref) | 1.50 (0.89, 2.53) | 0.124 | 1.91 (1.17, 3.10) | 0.009 | 2.80 (1.72, 4.53) | <0.0001 | 1.28 (1.13, 1.46) | 0.0001 |
Model 5b | (ref) | 1.59 (0.94, 2.68) | 0.079 | 2.12 (1.30, 3.44) | 0.002 | 3.64 (2.26, 5.87) | <0.0001 | 1.41 (1.25, 1.60) | <0.0001 |
Model 5c | (ref) | 1.46 (0.87, 2.46) | 0.149 | 1.70 (1.04, 2.77) | 0.033 | 2.32 (1.42, 3.78) | 0.0007 | 1.19 (1.04, 1.35) | 0.008 |
Data are presented as hazard ratios (HRs) with 95% confidence intervals (CIs). Model 1: Model adjusted for age and sex. Model 2: Model 1 + family history of type 2 diabetes and BMI. Model 3: Model 2 + alcohol intake and smoking status. Model 4: Model 3 + TG. Model 5a: Model 4 + HOMA-IR. Model 5b: Model 4 + HOMA-β. Model 5c: Model 4 + HOMA-IR and HOMA-β. Abbreviations: BMI, body mass index; TG, triglycerides; HOMA, Homeostasis Model Assessment; IR, Insulin Resistance.