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Efficacy end points for the DASISION and ENESTnd trials
| DASISION13 | ENESTnd14 | ||||
|---|---|---|---|---|---|
| Imatinib | Dasatinib | Imatinib | Nilotinib | ||
| 400 mg daily (n = 260) | 100 mg daily (n = 259) | 400 mg daily (n = 283) | 300 mg twice daily (n = 282) | 400 mg twice daily (n = 281) | |
| Cumulative MMR at 5 y, % | 64 | 76 | 60 | 77 | 77 |
| MR4.5 at 5 y, % | 33 | 42 | 31 | 54 | 52 |
| Progression to AP/BC, % | 7 | 5 | 7 | 4 | 3 |
| 5-y OS (ITT), % | 90 | 91 | 92 | 94 | 96 |
| 5-y PFS, % | 86 | 85 | 91 | 92 | 96 |
AP, accelerated phase; BC, blast crisis; ITT, intention to treat.
