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Overall toxicities reported on randomized clinical trials
| Toxicity | ENESTnd | DASISION | BFORE | |||
|---|---|---|---|---|---|---|
| Imatinib 400 mg daily | Nilotinib 400 mg twice daily | Imatinib 400 mg daily | Dasatinib 100 mg daily | Imatinib 400 mg daily | Bosutinib 400 mg daily | |
| Grade 3 to 4 AE, % | 59 | 72 | NR | NR | 43 | 56 |
| Serious AE, % | 25 | 33 | NR | NR | NR | NR |
| AE leading to discontinuation, % | 14 | 20 | 7 | 16 | 11 | 14 |
NR, not reported.
