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Important idiosyncratic AEs
| AE | Imatinib 400 mg daily* | Nilotinib 400 mg twice daily | Dasatinib 100 mg daily | Bosutinib 400 mg daily |
|---|---|---|---|---|
| Range of vascular events, % | 1.1-2.5 | 15.9 | 4.7 | 1.5 |
| Range of pleural effusions, % | 0.8-1.9 | 0.7 | 28.0 | 1.5 |
| Pulmonary hypertension, % | 0.4 | 0.7 | 5.0 | NR |
| Range of grade 3 to 4 diarrhea, % | <0.1-3.6 | 2.5 | NR | 7.8 |
| Range of grade 3 to 4 abnormal liver function tests, % | 2.9-4.2 | 18.5 | NR | 24.3 |
Frequencies differ slightly by trial.
