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Composition of the mammalian SWI/SNF complex and Brg1 function in zebrafish heart regeneration. (A) Subunit composition of the mammalian SWI/SNF complex; (B) Cartoon showing how Brg1 regulates zebrafish cardiomyocyte proliferation and regeneration via a derepression mechanism. The injury-induced Brg1, via its interaction with Dnmt3ab, inhibits the expression of cdkn1c by increasing the methylation level of CpG sites at the cdkn1c promoter [61].
