Table 1.
Characteristics of participants with measurements of oxo8dG and oxo8Guo by statin use.
| Non-users (n = 2869) | Statin users (n = 551) | p-value | |
|---|---|---|---|
| Sex (male), n (%) | 1139 (40) | 266 (48) | < 0.001 |
| Age, mean (SD) | 52 (13) | 64 (9) | < 0.001 |
| Current smoking status, n (%) | <0.001 | ||
| Never | 1181 (41) | 165 (30) | |
| Former | 1060 (37) | 262 (48) | |
| Smoker | 479 (17) | 101 (18) | |
| Pack years median (IQR) | 0.6 (0.0, 16.0) | 8.8 (0.0, 28.8) | < 0.001 |
| BMI groups, n (%)* | <0.001 | ||
| Normal | 1159 (40) | 147 (27) | |
| Underweight | 31 (1) | 3 (1) | |
| Overweight | 1131 (39) | 253 (46) | |
| Obese cl. I | 414 (14) | 108 (20) | |
| Obese cl. II | 99 (4) | 31 (6) | |
| Obese cl. III | 29 (1) | 6 (1) | |
| Waist hip ratio, mean (SD) | 0.91 (0.86) | 0.94 (0.09) | 0.455 |
| Hypertension, n (%) | 480 (17) | 346 (63) | < 0.001 |
| Type 2 diabetes, n (%) | 48 (2) | 100 (18) | < 0.001 |
| HbA1c (mmol/mol), median (IQR) | 37 (34, 39) | 40 (37, 43) | < 0.001 |
| Ischemic disease, n (%)† | 48 (1.7) | 144 (26.1) | < 0.001 |
| Stroke, n (%) | 30 (1.0) | 53 (9.6) | < 0.001 |
| Myocardial infarction, n (%) | 14 (0.5) | 63 (11.4) | < 0.001 |
| Ischemic heart disease, n (%)‡ | 12 (0.4) | 67 (12.2) | < 0.001 |
| Cancer, n (%)§ | 159 (5.5) | 74 (13.4) | < 0.001 |
| Total cholesterol (mmol/l), mean (SD) | 5.57 (1.01) | 4.85 (1.06) | < 0.001 |
| LDL-C (mmol/l), mean (SD) | 3.21 (0.87) | 2.41 (0.88) | < 0.001 |
| HDL-C (mmol/l), mean (SD) | 1.61 (0.49) | 1.56 (0.49) | 0.014 |
| eGFR (µmol/l), median (IQR) | 82 (72, 91) | 76 (65, 87) | < 0.001 |
| Leisure time physical activity, n (%)ǁ | 0.001 | ||
| Group I: Mainly passive activity | 149 (5) | 33 (6) | |
| Group II: Light activity | 1364 (48) | 292 (53) | |
| Group III: Moderate activity | 1159 (40) | 185 (34) | |
| Group IV: Strenous activity | 150 (5) | 22 (4) | |
BMI, body mass index; HbA1c, glycated hemoglobin; LDL-C, low density lipoprotein cholesterol; HDL-C, high density lipoprotein cholesterol; eGFR, estimated glomerular filtration rate.
BMI groups: Normal, 18.5–24.9 kg; Underweight, < 18.5 kg; Overweight, 25.0–29.9 kg; Obese cl. I, 30.0–34.9 kg; Obese cl. II, 35.0–39.9 kg; Obese cl. III, ≥ 40 kg.
Ischemic heart disease or prior myocardial infarction or prior stroke.
Arteriosclerosis without prior myocardial infarction.
Current or prior cancer diagnosis.
Leisure time physical activity groups: Group I, mainly passive or light activity less than 2 h /wk.; Group II, light activity 2–4 h /wk.; Group III, light activity > 4 h /wk. or more strenuous activity 2–4 h /wk.; Group IV, more strenuous activity > 4 h /wk.