Figure 6.

The 10 days Cu site. No bone on the immediate implant vicinity. FBGC, foreign body giant cells; Oc, osteoclast actively remodeling old bone; Ob, Seam of osteoblasts producing new bone (part of the remodeling); IO, Implant/Osteotomy. Reaction to Cu divided in 3 zones, representing the 3 phenomena around implant materials in the bone: From the implant surface Lytic/Inflammatory area, Fibroproliferative area and Osteoproliferative area. The latter two represent an attempt to isolate the material from the marrow cavity. No osseointegration is viable at this time point. Theoretically, around Ti the same phenomena exist, but at a different balance, allowing for osseointegration, through direct bon-to-implant contact. Inflammatory area is highly vascularized. Scale bars 5 mm (left) and 100 µm (right).