Figure 2.

Potential BMAL1:CLOCK binding sites in the Npy,Agrp, and Pomc promotors. Putative binding sites for BMAL1:CLOCK are represented by gray ovals in the 2500-bp upstream (5′) region of the transcriptional start site (TSS, +1) of the (A) Npy, (B) Agrp, and (C) Pomc genes. The sequence of each binding site is written above the oval with the location relative to the TSS listed below. Where two or more sites are close together, the area is expanded and detailed in the inserts. Lighter ovals represent sites identified previously by Fick et al. (24), and darker ovals represent newly identified binding sites. All sequences are listed 5′ to 3′.