Table 1.
Summary of articles discussing IL-1 beta and epilepsy
| Study | Subjects | Method | Result/Conclusion |
|---|---|---|---|
| Vezzani et al. [45] | Kainite-intoxicated rats | Application of IL-1 beta in the hippocampus | IL-1 beta prolongs experimentally induced seizures |
| Vezzani et al. [44] | Bicuculline methiodide-intoxicated rodents | Intrahippocampal application of recombinant IL-1ra | IL-1ra inhibits experimentally induced seizures |
| Ravizza and Vezzani [46] | Male Sprague-Dawley rats | Immunohistochemical analysis following acute electrical stimulation in the ventral hippocampus | IL-1R1 plays different roles in neurons and in astrocytes during status epilepticus |
| Wang et al. [47] | Rats | Injection of right lateral ventricle with both IL-1 beta and glutamate | Interaction between IL-1 beta and metabotropic glutamate receptors in the onset of epilepsy |
| Pernot et al. [48] | C57BL/6 adult mice | Immunohistochemical analysis of tissue after mesiotemporal lobe epilepsy syndrome induced by intrahippocampal injection of kainate | Neuroinflammatory pathways are associated with epileptogenesis |
| Claycomb et al. [49] | IL-1 beta and IL1R1 -/- mice | Administration of chemoconvulsants | Produced more acute seizures |