Table 2.
Results from multivariable Model 2 (adjusted for caffeine) for ln(htTKV) and for mGFR
| Fixed Effects | Ln(htTKV) | mGFR | ||||
|---|---|---|---|---|---|---|
| Estimate | 95% CI | P-value | Estimate | 95% CI | P-value | |
| Age | 0.017 | 0.010, 0.025 | < 0.001 | −1.362 | − 1.700, − 1.024 | < 0.001 |
| Sex (Male) | 0.084 | − 0.040, 0.208 | 0.195 | −0.990 | −6.757, 4.780 | 0.741 |
| Race (White) | 0.083 | −0.101, 0.268 | 0.386 | −0.811 | −9.529, 7.880 | 0.858 |
| BMI | 0.006 | −0.006, 0.018 | 0.345 | −0.454 | −1.001, 0.094 | 0.112 |
| Smoke (Yes) | 0.072 | −0.091, 0.236 | 0.393 | 3.474 | −4.111, 11.053 | 0.378 |
| Hypertension (Yes) | 0.395 | 0.263, 0.527 | < 0.001 | −11.946 | −18.060, −5.821 | < 0.001 |
| Gene type | < 0.001* | 0.018* | ||||
| PKD1 + truncation | Reference | – | Reference | – | ||
| PKD1 + no truncation | − 0.082 | − 0.227, 0.064 | 1.475 | − 5.263, 8.208 | ||
| PKD2 + NMD | −0.504 | − 0.664, − 0.344 | 10.840 | 3.427, 18.237 | ||
| Caffeine (Any) | −0.146 | −0.295, 0.003 | 0.061 | 1.395 | −5.908, 8.714 | 0.713 |
| Caffeine:Time (Any) | 0.006 | 0.002, 0.011 | 0.007 | 0.069 | −0.495, 0.631 | 0.811 |
| Time | 0.045 | 0.041, 0.049 | < 0.001 | −2.696 | −3.187, −2.200 | < 0.001 |
| Random Effect | Variance | Standard Deviation | Variance | Standard Deviation | ||
| Patient | 0.224 | 0.474 | 425.0 | 20.62 | ||
| Residual | 0.016 | 0.127 | 372.8 | 19.31 | ||
*P-value based on F-test with 3 groups. NMD refers to no mutation detected in the genetic analysis