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. 2018 Dec 27;6:158. doi: 10.1186/s40425-018-0457-0

Fig. 3.

Fig. 3

PI3Kα/δ inhibitor promotes and sustain strong pro-inflammatory responses in CT-26 treated tumors. a Schematic of dosing and sample collection. b Heat map analysis of 268 differential gene expression between control and treated groups. c Top canonical pathways regulated at day 7 and day 14 after implant. d List of top upstream regulator ordered by p values and annotated for activation prediction. e Quantification of immune cellular subtypes based on RNAseq gene signatures within control and AZD8835 treated samples. f Quantification of immune cellular subtypes based on gene signatures between control and AZD8835 treated samples at 7 and 14 days time points. Statistical significance is indicated as p values, n = 6/group