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. 2018 Dec 27;12:145. doi: 10.1186/s12918-018-0668-5

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — Model comparison to training data for FGF or VEGF stimulation. a Normalized pERK dynamics in response to FGF concentrations ranging from 0.16 to 500 ng/ml. b Normalized VEGFR2 phosphorylation time course following stimulation with 5 ng/ml VEGF. c Dose response of pERK for FGF stimulation. d Normalized ERK phosphorylation time course upon stimulation with 50 ng/ml VEGF. The circles are experimental data. Curves are the mean values of the 16 best fits. Shaded regions show standard deviation of the fits