Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 27;12:145. doi: 10.1186/s12918-018-0668-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

PMC Copyright notice

Fig. 7 — Effect of varying VEGFR2 trafficking parameters on pERK response. a Maximum pERK, b T1, and (c) T2. The panels show the effect of 0.5 nM FGF (Yellow) or 0.5 nM VEGF (Blue) predicted using the fitted parameter values (“fitted” x-axis label). We ran the model with 0.5 nM VEGF when all of the VEGFR2 trafficking parameters are decreased (“all” x-axis label) to be the same as the FGFR trafficking rates shown in Additional file 1: Figure S5. Finally, we decreased each VEGFR2 trafficking parameter individually to be the same as the corresponding FGFR trafficking rate shown in Additional file 1: Figure S5. We omitted some points for T1 and T2 when the pERK does not reach the maximum value in two hours. Each dot represents one fit. Bars are median ± 95% confidence interval