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TRIF is required for caspase-11-dependent immune responses in endotoxemia. Serum IL-1α (a), IL-1β (b), TNF-α (c) and IL-6 (d) levels from mice of indicated genotypes following intraperitoneal injection with either 10 mg/kg LPS or saline. Serum samples were collected 16 h after LPS injection. *P<0.05; **P<0.01; ***P<0.001 (Student’s t-test). Graphs show the mean ± SD. Data are representative of at least three independent experiments
