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. 2018 Dec 27;24:66. doi: 10.1186/s10020-018-0065-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 2 — TRIF is required for caspase-11-dependent organ injury and lethality in endotoxemia. a Histology of the lungs from mice of indicated genotypes (n = 5) following intraperitoneal injection with either 10 mg/kg LPS or saline. Lungs were collected 8 h after LPS injection and then stained with H&E. b-c The serum alanine aminotransferase (ALT) and creatinine (Cre) levels from mice of indicated genotypes following intraperitoneal injection with either 10 mg/kg LPS or saline. Serum samples were collected 8 h after LPS injection. d Kaplan Meier survival curves for the indicated genotypes mouse strains subjected to 40 mg/kg LPS injection. *P<0.05; **P<0.01; ***P<0.001 (Student’s t-test and log-rank test for survival). Graphs show the mean ± SD. Data are representative of at least three independent experiments