Fig. 4.

Type 1 interferon signaling is critical for caspase-11-dependent immune responses, organ injury and lethality in endotoxemia. a-b Serum IL-1α and IL-1β levels from mice of indicated genotypes following intraperitoneal injection with either 10 mg/kg LPS or saline. c H&E staining of the lungs from mice of indicated genotypes (n = 5) following intraperitoneal injection with either 10 mg/kg LPS or saline. d-e The serum alanine aminotransferase (ALT) and creatinine (Cre) levels from mice of indicated genotypes following intraperitoneal injection with either 10 mg/kg LPS or saline. f Kaplan Meier survival curves for the indicated genotypes following intraperitoneal injection with 40 mg/kg LPS. *P<0.05; **P<0.01; ***P<0.001 (Student’s t-test and log-rank test for survival). Graphs show the mean ± SD. Data are representative of at least three independent experiments