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. 2018 Dec 27;24:66. doi: 10.1186/s10020-018-0065-y

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — GBPs are essential for caspase-11-dependent immune responses and lethality in endotoxemia. a-b Serum IL-1α and IL-1β levels from mice of indicated genotypes following intraperitoneal injection with either 10 mg/kg LPS or saline. c H&E staining of the lungs from mice of indicated genotypes (n = 5) following intraperitoneal injection with either 10 mg/kg LPS or saline. d-e The serum alanine aminotransferase (ALT) and creatinine (Cre) levels from mice of indicated genotypes following intraperitoneal injection with either 10 mg/kg LPS or saline. f Kaplan Meier survival curves for the indicated genotypes following intraperitoneal injection with 40 mg/kg LPS .*P<0.05; **P<0.01; ***P<0.001 (Student’s t-test and log-rank test for survival). Graphs show the mean ± SD. Data are representative of at least three independent experiments