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. 2018 Nov 24;14:101–113. doi: 10.1016/j.omtn.2018.11.009

Figure 3.

Figure 3

miR-138-Rich γδTDEs Directly Inhibit the Growth of Tumor

(A) The viability of OSCC cells treated by liposome and γδTDEs carrying either scramble miRNA or miR-138 were measured by CCK-8 assay. Data represent at least three experiments done in triplicate with 10 biological replicates. (B) Representative flow-cytometry-based apoptosis assay of OSCC cells treated by liposome and γδTDEs carrying either scramble miRNA or miR-138. Experiments were performed in triplicate. (C) Cell cycle of OSCC cells treated by liposome and γδTDEs carrying either scramble miRNA or miR-138 was analyzed by propidium iodide staining and flow cytometry. Data represent at least three experiments done in triplicate. (D) Cal-27 xenograft bearing nude mice received injection of liposome and γδTDEs carrying either scramble miRNA or miR-138, respectively. Growth curve of xenograft tumors was monitored. n = 6 in each group. (E) Representative image of immunostaining of Ki-67 (upper panel) and TUNEL assay (lower panel) in xenograft tumors. Scale bars: 100 μm. *p < 0.05.