Figure 5.

miR-138-Rich γδTDEs Stimulate Anti-tumor Immunity

C3H mice (A) and nude mice (B) received weekly i.v. injection of either liposome or γδTDEs for 6 weeks. Twenty-four hours after the sixth immunization, 1 × 10⁷ SCC-VII cells were subcutaneously injected, and tumor growth was monitored weekly. n = 6 in each group. Thunderbolt indicates subcutaneous (s.c.) injection of cancer cells. (C) Representative flow cytometry analysis (left upper panel) and immune-florescence staining (left middle panel) showing the infiltration of CD3⁺ lymphocytes in the tumor on C3H mice. Flow cytometry analysis (left bottom panel) of CD4⁺ and CD8⁺ T cells in the CD3⁺ population. Quantitative analysis of flow cytometry data of CD3⁺ T cells (right upper panel) and CD4⁺/CD8⁺ T cells (right lower panel). *p < 0.05.