Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Nov 9;17(1):230–236. doi: 10.3892/etm.2018.6949

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright: © Zhao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

PMC Copyright notice

Figure 4. — Berberine treatment improves anoxia-reoxygenation injury via the p38 MAPK-mediated NF-κB signaling pathway. Phosphorylated p38 MAPK and NF-κB (A) mRNA and (B) protein expression in myocardial cells isolated from a mouse model of anoxia-reoxygenation injury. p38 MAPK overexpression ameliorates the berberine-induced upregulation in NF-κB (C) activity and (D) expression in myocardial cells. p38 MAPK overexpression suppresses the berberine-induced overexpression of Bcl-2 and Bcl-xl (E) mRNA and (F) protein in myocardial cells. (G) Effects of p38 MAPK overexpression on Berberine-inhibited myocardial apoptosis of myocardial cells isolated from experimental mice determined by TUNEL. (H) Effects of p38 MAPK or NF-κB inhibitor on the apoptosis of myocardial cells isolated from PBS-treated experimental mice determined by TUNEL. **P<0.01. MAPK, mitogen-activated protein kinase; NF, nuclear factor; Bcl, B-cell lymphoma; xl, extra large.