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. 2018 Nov 23;17(1):773–781. doi: 10.3892/etm.2018.7008

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Copyright: © Chao et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — The expression of miR-96, Smad7 and COL1A1 in KFs and NFs. (A) The miR-96 expression level was upregulated in KFs compared with that in NFs. The expression of Smad7 was decreased in KFs compared with that in NFs at both the (B) mRNA and (C) protein levels. Black circles indicate the Smad7 expression level in the keloid of case #5 and in the autologous normal skin control (#5′) of case #5. (D) An inverse correlation of Smad7 and the miR-96 mRNA level was observed in the keloid samples. (E) A positive correlation between Smad7 and miR-96 was revealed in the keloid samples. Masson's staining of two keloid tissue samples: (F) Case #5 and (G) case #9. Case #5 exhibited a relatively thicker dermis and stronger staining of the collagen fibers, a higher miR-96 expression, and a relatively lower Smad7 expression, compared with that of case #9. Red arrows indicate the KFs in the tissue samples of cases #5 and #9. *P<0.05 and ***P<0.001, as indicated. miR, microRNA; Smad, mothers against decapentaplegic homolog; COL1A1, collagen subunit 1α1; KF, keloid-derived fibroblast; NF, normal skin-derived fibroblast.