Table 2.
Adjusted odds ratios for high (≥56) vs. low (< 56) scoring on the Conner's Adolescents Self-Report Scale subscales for ADHD-index and DSM-IV total according to genetic variants associated with blood manganese levels.
| ADHD-index | DSM-IV total | |||||
|---|---|---|---|---|---|---|
| Genotype | Na | OR (95% CI)b | p | Na | OR (95% CI)b | p |
| SLC30A10 rs1776029 | ||||||
| GG | 39/319 | 1.00 (referencec) | – | 46/312 | 1.00 (referencec) | – |
| GA | 23/173 | 1.06 (0.60-1.86) | 0.84 | 38/158 | 1.62 (1.00-2.62) | 0.05 |
| AA | 5/22 | 1.43 (0.49-4.19) | 0.51 | 9/18 | 3.08 (1.25-7.57) | 0.01 |
| SLC30A10 rs12064812 | ||||||
| CC/TC | 24/266 | 1.00 (referencec) | – | 39/251 | 1.00 (referencec) | – |
| TT | 43/248 | 2.10 (1.21-3.66) | 0.008 | 54/237 | 1.51 (0.95-2.40) | 0.08 |
| SLC39A8 rs13107325 | ||||||
| TT/CT | 4/99 | 1.00 (referencec) | – | 12/91 | 1.00 (referencec) | – |
| CC | 63/415 | 4.16 (1.45-11.9) | 0.008 | 81/397 | 1.68 (0.87-3.27) | 0.12 |
DSM-IV total, Diagnostic and Statistical Manual of Mental Disorders, 4th Edition total score of inattention and hyperactivity/impulsivity; OR, odds ratio; CI, confidence interval.
a
Number of children with high (≥56) vs. low (< 56) scoring for ADHD-index and DSM-IV total.
b
Adjusted for age, gender, body mass index, ferritin, and Pb levels, Mn in soil, drinking habits, Socioeconomic status, maternal education, and parity.
c
Reference genotypes are associated with lowest manganese concentrations in blood.