Figure 1.

Profiles of differentially expressed lncRNAs between the two groups. (A) Hierarchical clustering analysis of 40 lncRNAs that were aberrantly expressed between children with HSPN (sick173, sick105, sick303, sick64, sick111 and sick87) and HC (healthy460, healthy472, healthy473 and healthy475). Red and green indicate high and low relative expression, respectively. P<0.05 was considered to indicate a statistical significant difference. FC≥1.5 indicated upregulation and <0.67 indicated downregulation. (B) Scatter plot of aberrant expression of lncRNAs between the HSPN and HC libraries. Red indicates upregulated lncRNAs [log₂(HSPN/HC)>0], blue indicates lncRNAs with no change in expression between HSPN and HC libraries, green indicates downregulated lncRNAs [log₂(HSPN/HC)<0]. (C) Volcano plot of aberrant lncRNA expression. The vertical green lines delineate a 1.5-fold upregulation and 0.67-fold downregulation of lncRNAs, and the horizontal line represents P=0.05. Red plots on the right side represent 34 upregulated lncRNAs with FC≥1.5 and corrected P<0.05. Red plots on the left side represent 786 down-regulated lncRNAs with FC<0.67 and corrected P<0.05. lncRNA, long non-coding RNA; HSPN, Henoch-Schönlein purpura nephritis; HC, healthy controls; FC, fold change; NR, nitrate reductase.