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. 2018 Nov 9;17(1):79–90. doi: 10.3892/etm.2018.6947

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Copyright: © Zhang et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 8. — Analysis of bone regeneration of the femur defect by using HE and Masson staining. (A) HE and Masson stained tissue sections of bone regeneration in the defect areas, implanted with PCL, PCL/COL or PCL/COL/SIM-PLGA constructs, at 3 months after surgery. (B) The SIM-loaded scaffold demonstrated the most robust osteogenic activity, and the majority of the defect area in the SIM-loaded scaffold group was filled with eosin-stained newly formed bone tissue. *P<0.05, as indicated. S, scaffolds; NB, newly formed bone; FB, fibrosis; PLGA, poly(lactic-co-glycolic acid); SIM, simvastatin; COL, collagen; PCL, poly(ε-caprolactone); HE, hematoxylin and eosin.